Storage stability of hydrolyzed palm kernel oil and red palm super olein blend and its softgel capsule
DOI:
https://doi.org/10.22302/iribb.jur.mp.v93i1.607Keywords:
Digestive health, monolaurin, phytonutrient, shelf lifeAbstract
Hydrolyzed palm kernel oil (PKO) and red palm super olein (RPSO) blend, known as HPRB, is a novel product with potential benefits for digestive health. This blend combines the antimicrobial properties of hydrolyzed PKO with the antioxidant effects of RPSO. However, the long-term stability of HPRB under different storage conditions is crucial to ensure its efficacy and safety. This study aims to evaluate the storage stability of HPRB in its oil form and as a softgel capsule. The research investigated the impact of various storage conditions on the phytonutrient content, fatty acid composition, and acylglycerol profile of HPRB. The results showed that cool and dark storage conditions best preserve the phytonutrient content of HPRB. The fatty acid and acylglycerol compositions of HPRB remained stable regardless of the storage conditions. Accelerated stability testing of HPRB softgel capsules demonstrated excellent stability across various parameters, including physical characteristics, microbiological quality, and chemical stability. Shelf-life estimation indicated a relatively long shelf life for the softgel capsules under accelerated conditions. These results suggest that HPRB, particularly when stored appropriately or encapsulated in softgel form, has the potential for long-term stability and safe use.
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Atencio, S., Verkempinck, S. H. E., Reineke, K., Hendrickx, M., & Van Loey, A. (2022). Heat and Light Stability of Pumpkin-Based Carotenoids in a Photosensitive Food: A Carotenoid-Coloured Beverage. Foods, 11(3), 1–17. https://doi.org/10.3390/foods11030485
Balmus, I. M., Ilie-Dumitru, O., Ciobica, A., Cojocariu, R. O., Stanciu, C., Trifan, A., Cimpeanu, M., Cimpeanu, C., & Gorgan, L. (2020). Irritable bowel syndrome between molecular approach and clinical expertise—searching for gap fillers in the oxidative stress way of thinking. Medicina (Lithuania), 56(1), 1–20. https://doi.org/10.3390/medicina56010038
Barberis, E., Amede, E., Tavecchia, M., Marengo, E., Cittone, M. G., Rizzi, E., Pedrinelli, A. R., Tonello, S., Minisini, R., Pirisi, M., Manfredi, M., & Sainaghi, P. P. (2021). Understanding protection from SARS-CoV-2 using metabolomics. Scientific Reports, 11(1), 1–10. https://doi.org/10.1038/s41598-021-93260-2
Chaturvedi, D., Srivastava, R., Shukla, S. K., & Tiwari, A. K. (2020). A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS). International Journal of Contemporary Medical Research [IJCMR], 7(3), 4–9. https://doi.org/10.21276/ijcmr.2020.7.3.31
Fiedor, J., & Burda, K. (2014). Potential role of carotenoids as antioxidants in human health and disease. Nutrients, 6(2), 466–488. https://doi.org/10.3390/nu6020466
González-González, O., Ballesteros, M. P., Torrado, J. J., & Serrano, D. R. (2023). Application of Accelerated Predictive Stability Studies in Extemporaneously Compounded Formulations of Chlorhexidine to Assess the Shelf Life. Molecules, 28(23). https://doi.org/10.3390/molecules28237925
Krislee, A., Fadly, C., Nugrahaningsih, D. A. A., Nuryastuti, T., Nitbani, F. O., Jumina, & Sholikhah, E. N. (2019). The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates of Staphylococcus epidermidis. BMC Proceedings, 13(Suppl 11), 9–14. https://doi.org/10.1186/s12919-019-0174-9
Maia, C. G. C., De Araujo, B. C. R., De Freitas-Marques, M. B., Da Costa, I. F., Yoshida, M. I., Da Nova Mussel, W., Sebastiaõ, R. de C. O., & Reboucąs, J. S. (2021). Thermal Stability Kinetics and Shelf Life Estimation of the Redox-Active Therapeutic and Mimic of Superoxide Dismutase Enzyme, Mn(III) meso-Tetrakis(N-ethylpyridinium-2-yl)porphyrin Chloride (MnTE-2-PyPCl5, BMX-010). Oxidative Medicine and Cellular Longevity, 2021(Iii). https://doi.org/10.1155/2021/7003861
Ngatirah, N., Hidayat, C., Rahayu, E. S., & Utami, T. (2022). Enzymatic Glycerolysis of Palm Kernel Olein-Stearin Blend for Monolaurin Synthesis as an Emulsifier and Antibacterial. Foods, 11(16). https://doi.org/10.3390/foods11162412
Park, J.-M., Koh, J.-H., & Kim, J.-M. (2018). Predicting Shelf-life of Ice Cream by Accelerated Conditions. Korean Journal for Food Science of Animal Resources, 38(6), 1216–1225. https://doi.org/10.5851/kosfa.2018.e55
Peedikayil, F. C., Sreenivasan, P., & Narayanan, A. (2015). Effect of coconut oil in plaque related gingivitis - A preliminary report. Nigerian Medical Journal, 56(2), 143. https://doi.org/10.4103/0300-1652.153406
Seleem, D., Freitas-Blanco, V. S., Noguti, J., Zancope, B. R., Pardi, V., & Murata, R. M. (2018). In vivo antifungal activity of monolaurin against Candida albicans biofilms. Biological and Pharmaceutical Bulletin, 41(8), 1299–1302. https://doi.org/10.1248/bpb.b18-00256
Semitsoglou-Tsiapou, S., Meador, T. B., Peng, B., & Aluwihare, L. (2022). Photochemical (UV–vis/H2O2) degradation of carotenoids: Kinetics and molecular end products. Chemosphere, 286(P3), 131697. https://doi.org/10.1016/j.chemosphere.2021.131697
Šeregelj, V., Estivi, L., Brandolini, A., Ćetković, G., Tumbas Šaponjac, V., & Hidalgo, A. (2022). Kinetics of Carotenoids Degradation during the Storage of Encapsulated Carrot Waste Extracts. Molecules, 27(24). https://doi.org/10.3390/molecules27248759
Shahidi, F., & De Camargo, A. C. (2016). Tocopherols and tocotrienols in common and emerging dietary sources: Occurrence, applications, and health benefits. International Journal of Molecular Sciences, 17(10), 1–29. https://doi.org/10.3390/ijms17101745
Song, J., Wei, Q., Wang, X., Li, D., Liu, C., Zhang, M., & Meng, L. (2018). Degradation of carotenoids in dehydrated pumpkins as affected by different storage conditions. Food Research International, 107(February), 130–136. https://doi.org/10.1016/j.foodres.2018.02.024
Tian, T., Wang, Z., & Zhang, J. (2017). Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity, 2017. https://doi.org/10.1155/2017/4535194
Yuksel, M., Ates, I., Kaplan, M., Arikan, M. F., Ozin, Y. O., Kilic, Z. M. Y., Topcuoglu, C., & Kayacetin, E. (2017). Is Oxidative Stress Associated with Activation and Pathogenesis of Inflammatory Bowel Disease? Journal of Medical Biochemistry, 36(4), 341–348. https://doi.org/10.1515/jomb-2017-0013
Zeng, Z., Zdzieblik, D., Centner, C., Brauchle, C., Gollhofer, A., & König, D. (2020). Changing dietary habits increases the intake of antioxidant vitamins and reduces the concentration of reactive oxygen species in blood: a pilot study. International Journal of Food Properties, 23(1), 1337–1346. https://doi.org/10.1080/10942912.2020.1800727
Zhang, Q., Yi, D., Ji, C., Wu, T., Wang, M., Guo, S., Wang, L., Zhao, D., & Hou, Y. (2022). Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon Pathway. Frontiers in Immunology, 12(January), 1–10. https://doi.org/10.3389/fimmu.2021.797476
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Copyright (c) 2025 Manda Edy Mulyono, Ilmi Fadhilah Rizki, Frisda Rimbun Panjaitan, Brahmani Dewa Bajra

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