Recent studies of synthetic antibody-based 3-MCPD determination technology

Authors

DOI:

https://doi.org/10.22302/iribb.jur.mp.v89i1.402

Keywords:

3-MCPD, molecularly imprinted polymer (MIP), MIP-based SPE, MIP-based sensor

Abstract

3-Chloro-1,2-propanediol (3-MCPD) is classified by the International Agency for Research on Cancer as carcinogenic material. 3-MCPD will also become one of the European Union's requirements, proposing the maximum level of the 3-MCPD in palm oil until 2.5 ppm. Although the reported technologies GCMS and HPLC-FLD demonstrated high sensitivity and selectivity on 3-MCPD determination, those technologies invest in chemical and time-consuming sample preparation and analysis. Molecularly imprinted polymer (MIP), or a synthetic antibody, can be used to recognize 3-MCPD. MIP is more robust under extreme environments such as temperature and pH. This paper, therefore, aims to discuss the application of MIP on sample extraction and analysis to detect 3-MCPD. MIP is synthesized by polymerization of functional monomers surrounding 3-MCPD as a template. 3-MCPD is then removed from the MIP, leaving active cavities. Thus, these sites can either covalently or non-covalently rebind to 3-MCPD. Computational or empirical studies could investigate the composition of MIP. MIP can be manufactured as MIP-based solid phase extraction (MIPSPE) and MIP-based sensor. Both applications showed significant analytical parameters, such as recovery higher than 90% and detection limit lower than 2.5 ppm.  Therefore, the application of MIP can be flexible for sample preparation and analysis on the 3-MCPD determination. MIP-based technology would be a prospective instrument to detect 3-MCPD.  In the future, producing MIP on an industrial scale will be a challenge to monitor the 3-MCPD level in palm oil.

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Submitted

13-11-2020

Accepted

26-04-2021

Published

28-05-2021

How to Cite

MUNAWAR, H., LUNA, P., KRESNAWATY, I., & WIDIASTUTI, H. (2021). Recent studies of synthetic antibody-based 3-MCPD determination technology. Menara Perkebunan, 89(1). https://doi.org/10.22302/iribb.jur.mp.v89i1.402

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